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Buffer Dilution Requires Low Shear, Low Pulsation and Stable, Accurate Flow Rates

Four-piston diaphragm pumps, pump controllers and flow sensors/meters from PSG® Biotech are the preferred choice for ensuring a successful buffer dilution operation, resulting in the production of biologics that are safe and efficient for human administration.

Our Solutions for Buffer and Media Preparation for the Biopharma Industry

In the pharmaceutical industry, precision and reliability are critical, especially in the preparation of buffers and media. At PSG Biotech, we offer comprehensive solutions tailored to the high demands of buffer and media preparation. Our portfolio includes cutting-edge Quattroflow® pumps, single-use pump systems as well as advanced flow measurement and control technologies designed to enhance operational efficiency and product safety.

The Importance of Buffer and Media Preparation in the Biopharma Industry

Media preparation involves creating nutrient-rich solutions that support the growth and proliferation of cells, particularly in cell culture processes used for producing biopharmaceuticals like vaccines, antibodies or other therapeutic proteins.

Buffers are solutions that resist changes in pH when acids or bases are added. They are essential in bioprocessing because they maintain the pH at levels optimal for enzymatic activities, protein stability and other biochemical processes.

Both components are essential for creating the right environment for biological reactions and processes.

Key Operational Variables in Buffer and Media Preparation

Our flow control solutions specifically address and control two significant operational variables in buffer and media preparation:

1. Accurate Flow Control
The ability to precisely control the flow rate is crucial in buffer and media preparation, as it directly affects the consistency and quality of the final product. Our pumps and flow meters provide exceptional accuracy, ensuring that the exact volume of fluids are transferred as required.

2. Linear Flow Characteristic
Consistent flow is essential for maintaining the integrity of sensitive biological substances. The linear flow characteristic of our flow control solutions ensures that fluids are handled gently, preserving their biochemical properties and activity.

Achieving Peak Performance

Only when these two variables—accurate flow control and linear flow characteristic—are properly achieved and maintained will peak performance be realized for buffer and media preparation. Maintaining consistent flow rates and characteristics ensures that each batch of buffer or media meets the required specifications, leading to uniform product quality. Optimal flow control reduces wastage and enhances the efficiency of downstream processes, such as chromatography, filtration and fermentation.

Our state-of-the-art technology and robust product designs ensure these critical parameters are met, providing the foundation for high-quality pharmaceutical production. By integrating our reliable, scalable solutions into your buffer and media preparation processes, you can enhance the efficiency, consistency and quality of your biopharmaceutical manufacturing operations.


Why PSG Biotech Solutions Are the Best Option for Buffer and Media Prep

Quattroflow Four-Piston Diaphragm Pumps

Quattroflow Four-Piston Diaphragm Pumps utilize a unique, single-use diaphragm design, making them ideal for handling delicate biologic fluids without compromising on sterility or efficiency.

SumoFlo® Coriolis Flow
Meters

SumoFlo Coriolis Flow Meters offer ±1% flow-rate reading accuracy that is unaffected by flow regime or variations to the velocity profile, allowing for accurate measurements of liquids transferred for buffer and media preparation.

BioProTT™ FlowSU
System

The award-winning BioProTT™ FlowSU System is easily integrated with the pump via a smart connection that enables it to deliver highly accurate flow measurement without adding obstructions within the flow path.

BioProTT™ Clamp-On
Sensors

BioProTT™ Clamp-On Sensors use the ultrasonic transit-time method for noninvasive measurement, which is a critical concern when transferring hygienic liquids for use in buffer and media preparation.


Product Selector

As your trusted industry leader in flow transfer and measurement solutions, PSG Biotech offers a comprehensive range of pumps and flow meters tailored to meet your specific biologic flow-management requirements.

Use the selector tool below to identify your desired flow rate range. Then, explore our extensive selection of products to find the perfect solution for your needs. Click on the product name for more information.



Flow (LPM)

0.002 - 0.05

0.002

SumoFlo U08

0.005 - 0.05

0.005

QB2

0.038 - 0.38

0.038

QB25**

0.001 - 0.5

0.001

QF30

0.02 - 1.5

0.02

SumoFlo 031

0.017 - 2

0.017

BioProTT™ 1/8"

0.02 - 3

0.02

QF150

0.5 - 5

0.5

SumoFlo 062

0.1 - 6

0.1

BioProTT™ 3/16"

0.1 - 8

0.1

BioProTT™ 1/4"

0.9 - 9

0.9

SumoFlo 063

0.1 - 10

0.1

BioProTT™ 3/8"

2 - 20

2

SumoFlo 082

0.3 - 20

0.3

BioProTT™ 1/2"

0.1 - 20

0.1

QF1200

4 - 40

4

SumoFlo 151

0.42 - 41.67

0.42

QF2500

6 - 60

6

SumoFlo 152

2 - 75

2

BioProTT™ 3/4"

2.5 - 80

2.5

BioProTT™ FlowSu 1"

0.83 - 83.33

0.83

QF4400

0.83 - 83.33

0.83

QF5050

0.83 - 100

0.83

QF5K

2 - 100

2

BioProTT™ 1"

10 - 100

10

SumoFlo 153

8.33 - 166.67

8.33

QF10K

16.67 - 266.67

16.67

QF20K