Our Solutions for Centrifugal Applications in Biopharma

PSG Biotech offers best-in-class pumps, flow sensors, meters and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during depth filtration. Our advanced technology ensures optimal performance in depth filtration systems, which are essential for the purification and processing of biopharmaceutical products.

The Importance of Centrifugation in the Biopharma Industry

Centrifugation is a critical process in the biopharmaceutical industry, used for separating and purifying cells, proteins, nucleic acids and other biological materials. By applying centrifugal force, this technique separates components based on their size, shape and density, making it a key step in the purification of vaccines, monoclonal antibodies and therapeutic proteins. Given the complexity and sensitivity of biologic products, centrifugal processes must be conducted with precision and care to maintain product integrity and ensure patient safety.

Application-Specific Solutions

Purification:
Centrifugation is widely used for the purification of biologic products, including monoclonal antibodies, recombinant proteins and cell culture fluids. Our Quattroflow pumps and control systems ensure precise control over flow rate and pressure, which are critical for achieving high purity and yield. By maintaining optimal centrifugal conditions, our solutions enhance the efficiency and reliability of purification processes.

Shear-Sensitive Products:
Many biopharmaceutical products, such as therapeutic proteins and vaccines, are highly sensitive to shear forces. Our Quattroflow pumps are specifically engineered to handle these shear-sensitive products with care, minimizing the risk of denaturation and maintaining product efficacy throughout the centrifugal process.

Cell Culture Clarification:
Centrifugation is essential for harvesting cells from culture media by separating cells from the surrounding fluid. Accurate control of flow rate and pressure is vital for maintaining cell viability and maximizing recovery. Our systems provide the necessary precision and reliability to support high-quality harvesting for cell culture.

Viral Vector Purification:
In the production of gene therapies and viral vaccines, centrifugation is used for the purification of viral vectors. Ensuring low-shear and constant-flow conditions helps preserve the integrity of viral particles, enhancing the quality and effectiveness of the final product. Our solutions offer the necessary control and precision to achieve high levels of viral vector purity.

Plasmid DNA Isolation:
Centrifugation is commonly employed in the isolation of plasmid DNA. Precise control over centrifugal force and flow rate ensures efficient separation and high purity of plasmid DNA, which is crucial for downstream applications in gene therapy and molecular biology.

Continuous and Batch Processing:
Our centrifugal systems are designed to support both continuous and batch processing, providing flexibility to meet varying production demands. The ability to seamlessly transition between different processing modes enhances operational efficiency and scalability, allowing for the production of larger quantities of biopharmaceutical products without compromising quality.