Our Solutions

PSG Biotech offers best-in-class pumps, flow sensors, meters and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during bulk filling processes. Our advanced technology ensures optimal performance in bulk filling systems, which are crucial for maintaining the integrity and consistency of pharmaceutical production.

The Importance of Chromatography in the Pharma Industry

Chromatography is a pivotal technique in the pharmaceutical industry used for the purification and separation of complex mixtures into their individual components. This process is essential for ensuring the purity, potency and safety of biopharmaceutical products, such as monoclonal antibodies, vaccines and therapeutic proteins. Accurate and efficient chromatography is vital for drug development, quality control and regulatory compliance.

Application-Specific Solutions

Resin Beads:
Selecting the appropriate resin beads is critical for effective purification in chromatography. For instance, protein A resins are commonly used for purifying monoclonal antibodies due to their high specificity and binding capacity. Other resins, such as cation and anion exchange resins, are used for separating charged molecules.

Cell Lines:
The choice of cell lines, such as CHO, HEK or HeLa, can impact the chromatography process. Each cell line has unique properties that influence the purification steps, including the type of contaminants and the required purification stringency.

Batch Processing:
Batch processing is a common approach in chromatography where each batch undergoes the purification process separately. This method allows for precise control over the purification conditions and is ideal for small-scale production or when dealing with sensitive biological materials.

Monoliths:
Monolithic columns are another chromatography tool that offers high resolution and speed. These are particularly useful in high-throughput applications and when working with large biomolecules.

By addressing these key operational variables and application-specific considerations, we ensure that our chromatography solutions meet the stringent requirements of the pharmaceutical industry, providing reliable and high-quality results for biopharmaceutical production.