Quattroflow Pumps

Quattroflow® and QB pumps both present a significant advantage in cell and gene therapy applications due to their unique features that cater to the specific needs of these therapies.

Quattroflow pumps are quaternary diaphragm pumps offers gentle, low-shear handling of fluids. This characteristic is crucial in cell and gene therapy applications where the integrity of cells and viral vectors must be preserved.

Applications in Cell & Gene Therapy:

1. Cell Harvesting and Processing: Quattroflow pumps are used in the harvesting and processing of cells, ensuring that the cells are not damaged during the transfer.
2. Media and Buffer Handling: QF pumps are used for pumping and transferring culture media and buffers, maintaining the quality of the fluids.
3. Filtration Processes: They are employed in filtration steps where maintaining cell viability is essential.
4. Formulation and Filling: In the formulation and final filling stages of cell and gene therapies, Quattroflow pumps provide precise and consistent dosing and delivery of therapeutic products into vials or syringes.

Advantages:

• Low shear and gentle pumping action, preserving cell and viral vector integrity.
• High accuracy and precision in fluid handling.
• Suitable for single-use systems, reducing the risk of cross-contamination.
• Scalable solutions for various stages of therapy development and production.

Flow Sensors

SumoFlo® Coriolis sensors are highly beneficial in cell and gene therapy applications due to their precise mass flow measurement and control capabilities.

Advantages:

1. High Accuracy: Provides precise mass flow measurements, crucial for maintaining the correct formulation and dosage of therapeutic products.
2. Single-Use Compatibility: Designed for single-use systems, reducing contamination risks and simplifying the process.
3. Versatility: Applicable in various stages of the cell and gene therapy production process, from upstream bioreactor feeding to downstream purification and final fill-finish operations.
4. Real-Time Monitoring: Enables real-time monitoring and control of critical process parameters, improving process reliability and product quality.
5. Scalability: Suitable for use in both small-scale clinical production and large-scale commercial manufacturing, supporting the scalable nature of cell and gene therapy production.

SumoFlo Coriolis sensors play a vital role in cell and gene therapy applications by providing accurate and reliable mass flow measurements. Their integration into single-use systems and various bioprocessing stages enhances process control, reduces contamination risks and ensures consistent product quality. This precision and reliability are critical for the successful development and manufacturing of cell and gene therapies, ultimately contributing to better patient outcomes.

QB Pumps

QB pumps are single-use, disposable pumps designed for accurate and controlled fluid dispensing. These pumps are particularly suitable for processes that require sterility and precision.

Quattroflow pumps are quaternary diaphragm pumps offers gentle, low-shear handling of fluids. This characteristic is crucial in cell and gene therapy applications where the integrity of cells and viral vectors must be preserved.

Applications in Cell & Gene Therapy:

1. Dispensing and Dosing: QB pumps are used in precise dispensing and dosing of reagents, cells and gene therapy vectors.
2. Bioreactors: QB can be easily integrated in the bioreactors for growing cells on the fixed bed bioreactors.
3. Single-Use Systems and Setups: QB pumps are ideal for single-use applications, reducing the risk of contamination and simplifying cleanup.
4. Formulation and Filling: Like Quattroflow pumps, QB pumps can be used for low-volume application in the formulation and filling of therapeutic products, providing accurate dosing and reducing waste.

Advantages:

• Disposable and single use, ensuring sterility and reducing contamination risk.
• High precision and repeatability (coefficient of variation) in fluid dispensing.
• Compact and easy to integrate into various systems.
• Cost-effective solution for single-use applications.

Both Quattroflow and QB pumps play crucial roles in cell and gene therapy applications by ensuring gentle handling and precise fluid management as well as maintaining sterility. Quattroflow pumps are favored for their low shear, gentle pumping action suitable for cell and viral vector handling, while QB pumps are preferred for their lower footprint, precise, disposable nature, ideal for single-use applications. Together, they contribute to the efficiency and effectiveness of cell and gene therapy processes.