Our Solutions for Depth Filtration in Biopharm Applications

PSG Biotech offers best-in-class pumps, flow sensors, meters and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during depth filtration. Our advanced technology ensures optimal performance in depth filtration systems, which are essential for the purification and processing of biopharmaceutical products.

The Importance of Depth Filtration in the Biopharma Industry

Depth filtration is a critical process in the biopharmaceutical industry, used for the clarification and purification of cell culture media, fermentation broths and other complex biological mixtures. This filtration method involves the use of thick filter media that capture contaminants within their depth, providing high capacity and efficiency for removing particulates, cell debris and other impurities. Depth filtration is crucial for ensuring the purity and quality of biologic products, which in turn impacts the safety and efficacy of the final pharmaceutical product.

Application-Specific Solutions

Purification:
Depth filtration is widely used for the purification of biologic products, including monoclonal antibodies, recombinant proteins and cell culture fluids. Our Quattroflow pumps and control systems ensure precise control over flow rate and pressure, which are critical for achieving high purity and yield. By maintaining optimal filtration conditions, our solutions enhance the efficiency and reliability of purification processes.

Shear-Sensitive Products:
Many biopharmaceutical products, such as therapeutic proteins and vaccines, are highly sensitive to shear forces. Our Quattroflow pumps are specifically engineered to handle these shear-sensitive products with care, minimizing the risk of denaturation and maintaining product efficacy throughout the depth filtration process.

Cell Culture Clarification:
Depth filtration is essential for clarifying cell culture media by removing cells, cell debris and other particulates. Accurate control of flow rate and pressure is vital for maintaining the clarity and quality of the culture media, which is necessary for subsequent downstream processing steps. Our systems provide the necessary precision and reliability to support high-quality cell culture clarification.

Viral Vector Purification:
In the production of gene therapies and viral vaccines, depth filtration is used for the purification of viral vectors. Ensuring low-shear and low-pulsation conditions helps preserve the integrity of viral particles, enhancing the quality and effectiveness of the final product. Our solutions offer the necessary control and precision to achieve high levels of viral-vector purity.

Buffer Exchange and Prefiltration:
Depth filtration is often employed for buffer exchange and prefiltration steps, where precise control over filtration parameters is crucial. Our solutions ensure that these processes are conducted efficiently, with minimal product loss and optimal buffer conditions.

Batch and Continuous Processing:
Our depth filtration systems are designed to support both batch and continuous processing, providing flexibility to meet varying production demands. The ability to seamlessly transition between different processing modes enhances operational efficiency and scalability, allowing for the production of larger quantities of biopharmaceutical products without compromising quality.