Our Solutions for Inline Buffer Dilution

PSG Biotech offers best-in-class pumps, flow sensors and meters, and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during inline buffer dilution processes. Our advanced technology ensures optimal performance in buffer management systems, which are crucial for maintaining the integrity and consistency of biopharmaceutical production.

Importance of Inline Buffer Dilution

Inline buffer dilution is a critical process in the pharmaceutical industry, particularly in the production and purification of biopharmaceuticals. It involves the precise mixing of concentrated buffer solutions with water to achieve the desired buffer strength in real time, without the need for large storage tanks. This method is highly efficient and cost effective, reducing the need for extensive buffer preparation and storage infrastructure.

Application-Specific Solutions

Buffer Management Systems:
Our buffer management systems are designed to handle various types of buffers commonly used in biopharmaceutical processes, including phosphate, acetate and tris buffers. These systems ensure precise control over buffer preparation and delivery, enhancing the efficiency and reliability of the entire production process.

Protein Purification:
Accurate buffer dilution is critical in protein purification processes, such as ion exchange and affinity chromatography. For example, maintaining the correct buffer conditions is essential when using protein A resins for antibody purification. Our solutions ensure that buffers are prepared accurately and consistently, which is vital for achieving high purity and yield of the target protein.

Cell Culture:
In cell culture processes, such as those involving CHO or HEK cells, buffer conditions must be carefully controlled to maintain cell viability and productivity. Our inline dilution systems ensure that the culture media are prepared with the correct buffer concentrations, supporting optimal cell growth and protein expression.

Batch Processing:
For batch processing applications, our inline buffer dilution systems provide the flexibility and precision needed to prepare buffers on demand. This reduces the need for large buffer storage tanks and simplifies the overall production process. The ability to produce buffers in real time also enhances process efficiency and reduces the risk of contamination.

Monolith Columns:
When using monolith columns for high-throughput chromatography, precise buffer conditions are essential for achieving high resolution and speed. Our solutions ensure that buffers are consistently prepared and delivered, supporting the optimal performance of monolith columns.