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Buffer Dilution Requires Low Shear, Low Pulsation and Stable, Accurate Flow Rates

Four-piston diaphragm pumps, pump controllers and flow sensors/meters from PSG® Biotech are the preferred choice for ensuring a successful buffer dilution operation, resulting in the production of biologics that are safe and efficient for human administration.

Our Solutions for Virus Filtration

PSG Biotech offers best-in-class pumps, flow sensors, meters and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during virus filtration processes. Our advanced technology ensures optimal performance in virus filtration systems, which are essential for maintaining virus safety and the integrity of biopharmaceutical products.

The Importance of Virus Filtration in the Pharma Industry

Virus filtration is a critical process in the biopharmaceutical industry, ensuring the safety and efficacy of biologic products by removing potential viral contaminants. This process is essential for producing vaccines, monoclonal antibodies and other therapeutic proteins. Given the complexity and sensitivity of biologic products, virus filtration must be conducted with precision and care to maintain product integrity and ensure patient safety.

Key Operational Variables in Virus Filtration

Our solutions specifically address and control two significant operational variables in the virus filtration process:

1. Low Shear
Maintaining low-shear conditions is crucial for protecting shear-sensitive products, such as proteins and viruses. High-shear forces can denature proteins and compromise the integrity of viral particles, reducing the efficacy of the final product. Our Quattroflow® pumps are designed to provide gentle, low-shear pumping action, preserving the structural integrity of sensitive biologics during the filtration process.

2. Low Pulsation at High Pressure
Consistent low-pulsation flow at high pressure is essential for effective virus filtration. Pulsations can disrupt the filtration process, leading to inconsistent results and potential damage to the filtration membranes. Our advanced flow sensors and control systems ensure a smooth and stable flow, even at high pressures, minimizing the risk of process interruptions and ensuring reliable outcomes.

Achieving Peak Performance

Only when these variables—low shear and low pulsation at high pressure—are properly achieved and maintained will the virus filtration process realize its peak performance level. Our state-of-the-art technology and robust design ensure that these critical parameters are met, providing reliable and high-quality results for biopharmaceutical production.

By integrating our advanced virus filtration solutions into your processes, you can enhance the efficiency, consistency and quality of your biopharmaceutical production, ensuring that your products meet the highest standards of purity and potency. This not only improves operational efficiency, but also ensures compliance with regulatory requirements and enhances patient safety.

Application-Specific Solutions

Virus Filtration:
Virus filtration is paramount for ensuring the virus safety of biopharmaceutical products. Our solutions are designed to meet stringent regulatory requirements, providing reliable and efficient virus removal. By maintaining low-shear and low-pulsation conditions , our systems help ensure that biologic products are free from viral contaminants, safeguarding patient health.

Shear-Sensitive Products:
Many biopharmaceutical products, such as monoclonal antibodies, vaccines and gene therapies, are highly sensitive to shear forces. Our Quattroflow pumps are specifically engineered to handle these shear-sensitive products with care, minimizing the risk of denaturation and maintaining product efficacy throughout the filtration process.

Vaccine Production:
In vaccine production, maintaining the integrity of viral particles is crucial. Our low-shear, low-pulsation pumping solutions ensure that viral vectors and antigens are preserved during filtration, enhancing the quality and effectiveness of vaccines.

Therapeutic Protein Purification:
Virus filtration is a key step in the purification of therapeutic proteins. Our advanced filtration systems provide the precision and reliability needed to remove viral contaminants while preserving the biological activity of proteins. This is particularly important for ensuring the potency and safety of therapeutic products.

Gene Therapy Manufacturing:
In gene therapy, viral vectors are used to deliver genetic material to target cells. Ensuring the purity and integrity of these viral vectors is critical for the success of gene therapies. Our virus filtration solutions offer the necessary control and precision to achieve high levels of viral vector purity, supporting the development of safe and effective gene therapies.

Continuous Processing:
Our virus filtration systems are designed to support both batch and continuous processing, providing flexibility to meet varying production demands. Continuous processing enhances operational efficiency and scalability, allowing for the production of larger quantities of biopharmaceutical products without compromising quality.


Why PSG Biotech Solutions Are the Best Option for Depth Filtration

Quattroflow Four-Piston Diaphragm Pumps

Providing low-shear pumping action that preserves the structural integrity of sensitive biologic products, Quattroflow Four-Piston Diaphragm Pumps are the leading choice for virus filtration.

SumoFlo® Coriolis Flow
Meters

Designed for efficiency, consistency and safety, SumoFlo Coriolis Flow Meters feature gamma-sterilizable wetted components, making them ideal for virus filtration.

BioProTT™ FlowSU
System

Optimal for virus filtration, BioProTT Flow SU Systems feature non-invasive flow measurement and accuracy within 2% without individual calibration.
 

BioProTT™ Clamp-On
Sensors

BioProTT Clamp-On Sensors are the ideal easy-to-install option for flow measurement in virus-filtration applications.
 


Product Selector

As your trusted industry leader in flow transfer and measurement solutions, PSG Biotech offers a comprehensive range of pumps and flow meters tailored to meet your specific biologic flow-management requirements.

Use the selector tool below to identify your desired flow rate range. Then, explore our extensive selection of products to find the perfect solution for your needs. Click on the product name for more information.



Flow (LPM)

0.002 - 0.05

0.002

SumoFlo U08

0.005 - 0.05

0.005

QB2

0.038 - 0.38

0.038

QB25**

0.001 - 0.5

0.001

QF30

0.02 - 1.5

0.02

SumoFlo 031

0.017 - 2

0.017

BioProTT™ 1/8"

0.02 - 3

0.02

QF150

0.5 - 5

0.5

SumoFlo 062

0.1 - 6

0.1

BioProTT™ 3/16"

0.1 - 8

0.1

BioProTT™ 1/4"

0.9 - 9

0.9

SumoFlo 063

0.1 - 10

0.1

BioProTT™ 3/8"

2 - 20

2

SumoFlo 082

0.3 - 20

0.3

BioProTT™ 1/2"

0.1 - 20

0.1

QF1200

4 - 40

4

SumoFlo 151

0.42 - 41.67

0.42

QF2500

6 - 60

6

SumoFlo 152

2 - 75

2

BioProTT™ 3/4"

2.5 - 80

2.5

BioProTT™ FlowSu 1"

0.83 - 83.33

0.83

QF4400

0.83 - 83.33

0.83

QF5050

0.83 - 100

0.83

QF5K

2 - 100

2

BioProTT™ 1"

10 - 100

10

SumoFlo 153

8.33 - 166.67

8.33

QF10K

16.67 - 266.67

16.67

QF20K