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Buffer Dilution Requires Low Shear, Low Pulsation and Stable, Accurate Flow Rates

Four-piston diaphragm pumps, pump controllers and flow sensors/meters from PSG® Biotech are the preferred choice for ensuring a successful buffer dilution operation, resulting in the production of biologics that are safe and efficient for human administration.

Our Solutions for Centrifugal Applications in Biopharma

PSG Biotech offers best-in-class pumps, flow sensors, meters and flow controls engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during bulk filling processes. Our advanced technology ensures optimal performance in bulk filling systems, which are crucial for maintaining the integrity and consistency of pharmaceutical production.

Importance of Bulk Filling

Bulk filling is a critical process in the pharmaceutical industry, especially during the final stages of drug manufacturing. It involves transferring large quantities of active pharmaceutical ingredients (APIs) and other biologic liquids into containers for storage, transport or further processing. This process requires precision and reliability to ensure that the correct volumes are delivered, maintaining the quality and efficacy of the pharmaceutical products.

Key Operational Variables

Our solutions specifically address and control two significant operational variables in the bulk filling process:

1. Stable & Accurate Flow Rates
Ensuring a stable and accurate flow rate is crucial for maintaining the consistency and quality of the filled product. Fluctuations in flow rate can lead to underfilling or overfilling containers, causing deviations in product quantity and potentially compromising the quality of the API. Our advanced Quattroflow® pumps are designed to provide a smooth and consistent flow, minimizing the risk of process interruptions and ensuring reliable outcomes.

2. Linear Flow Characteristic
A linear flow characteristic is essential for accurate and reproducible bulk filling. Nonlinear flow can cause uneven distribution of liquid, leading to variations in fill volume and inconsistent product quality.Our Quattroflow® pumps maintain a linear flow characteristic, ensuring that biologic liquids are evenly distributed and that the bulk filling process operates at optimal performance levels.

Achieving Peak Performance

Only when these variables—stable and accurate flow rate and linear flow characteristic—are properly achieved and maintained will the bulk filling process realize its peak performance level. Our state-of-the-art technology and robust design ensure that these critical parameters are met, providing reliable and high-quality results for pharmaceutical production.

By integrating our advanced bulk filling solutions into your processes, you can enhance the efficiency, consistency and quality of your pharmaceutical production, ensuring that your products meet the highest standards of purity and potency. This not only improves operational efficiency, but also ensures compliance with regulatory requirements and enhances patient safety.

Application-Specific Solutions

Bulk Filling Systems:
Our bulk filling systems are designed to handle various types of biologic liquids commonly used in pharmaceutical processes, including APIs, excipients and buffers. These systems ensure precise control over the filling process, enhancing the efficiency and reliability of the entire production process.

API Filling:
Accurate bulk filling is critical in the handling of APIs, which are the essential components of pharmaceutical products. Precise metering and filling ensure that each container receives the correct dosage of the API, which is vital for maintaining the potency and efficacy of the final product. Our solutions ensure that APIs are filled accurately and consistently, which is crucial for regulatory compliance and patient safety.

Sterile Filling:
In sterile filling processes, such as those used for injectable drugs, maintaining the sterility of the product is paramount. Our bulk filling systems are designed to operate in aseptic environments, ensuring that the biologic liquids are transferred and metered without contamination. This is especially important for products that are administered directly to patients, where sterility is critical.

Batch Processing:
For batch processing applications, our bulk filling systems provide the flexibility and precision needed to fill containers on demand. This reduces the need for large intermediate storage tanks and simplifies the overall production process. The ability to fill in real time also enhances process efficiency and reduces the risk of contamination.

Flexible Single-Use Containers:
When using flexible containers for bulk filling, precise control over the filling process is essential to avoid overfilling or damaging the containers. Our solutions ensure that the correct volume is delivered, maintaining the integrity of the containers and the quality of the product.


Why PSG Biotech Solutions Are the Best Option for Depth Filtration

Quattroflow Four-Piston Diaphragm Pumps

Quattroflow Four-Piston Diaphragm Pumps are designed for low-shear, low-pulsation transfer, making them ideal for bulk-filling applications.
 

SumoFlo® Coriolis Flow
Meters

Ensuring accuracy within ±1%, SumoFlo Coriolis Flow Meters are optimal for bulk-filling applications due to their precision regardless of fluid velocity profile.
 

BioProTT™ FlowSU
System

Ideal for single-use bulk-filling setups, BioProTT FlowSU Systems offer highly accurate flow measurement with integrated air and bubble-detection capabilities.

BioProTT™ Clamp-On
Sensors

BioProTT Clamp-On Sensors enable non-invasive measurement without adding shear stress, making them well suited for biopharmaceutical bulk filling.
 


Product Selector

As your trusted industry leader in flow transfer and measurement solutions, PSG Biotech offers a comprehensive range of pumps and flow meters tailored to meet your specific biologic flow-management requirements.

Use the selector tool below to identify your desired flow rate range. Then, explore our extensive selection of products to find the perfect solution for your needs. Click on the product name for more information.



Flow (LPM)

0.002 - 0.05

0.002

SumoFlo U08

0.005 - 0.05

0.005

QB2

0.038 - 0.38

0.038

QB25**

0.001 - 0.5

0.001

QF30

0.02 - 1.5

0.02

SumoFlo 031

0.017 - 2

0.017

BioProTT™ 1/8"

0.02 - 3

0.02

QF150

0.5 - 5

0.5

SumoFlo 062

0.1 - 6

0.1

BioProTT™ 3/16"

0.1 - 8

0.1

BioProTT™ 1/4"

0.9 - 9

0.9

SumoFlo 063

0.1 - 10

0.1

BioProTT™ 3/8"

2 - 20

2

SumoFlo 082

0.3 - 20

0.3

BioProTT™ 1/2"

0.1 - 20

0.1

QF1200

4 - 40

4

SumoFlo 151

0.42 - 41.67

0.42

QF2500

6 - 60

6

SumoFlo 152

2 - 75

2

BioProTT™ 3/4"

2.5 - 80

2.5

BioProTT™ FlowSu 1"

0.83 - 83.33

0.83

QF4400

0.83 - 83.33

0.83

QF5050

0.83 - 100

0.83

QF5K

2 - 100

2

BioProTT™ 1"

10 - 100

10

SumoFlo 153

8.33 - 166.67

8.33

QF10K

16.67 - 266.67

16.67

QF20K